Innovative Bioavailability Enhancement

STRATEGIC, EXPERIENCED BIOAVAILABILITY ENHANCEMENT SERVICES

Improving bioavailability is often critical to unlocking a molecule’s therapeutic potential. Our bioavailability enhancement services are built on proven science, practical decision-making and a clear focus on what will move your program forward.

By embedding bioavailability enhancement strategies within the broader development plan, we help ensure that gains in exposure translate into stable, scalable, and clinically viable drug products. The goal is insight without excess and delivering meaningful results while conserving time, costs, and material.

Integrated with formulation and process development

By embedding bioavailability enhancement strategies within the broader development plan, we help ensure that gains in exposure translate into stable, scalable and clinically viable drug products. The goal is insight without excess and delivering meaningful results while conserving time, cost and material.

Our bioavailability enhancement services include:

Spray Drying

Spray drying is well suited for drugs that are soluble in organic solvents but may be thermally unstable. Our spray drying services for amorphous solid dispersions help maximize kinetic drug solubility increasing drug absorption.

Hot Melt Extrusion

Hot melt extrusion is well suited for thermally stable drugs that may have poor solubility in organic solvents. Our hot melt extrusion services for amorphous solid dispersions help maximize kinetic drug solubility increasing drug absorption.

Nanomilling

Nanomilling, sometimes referred to as bead milling, is well suited for drugs with poor solubility in organic solvents that are thermally unstable or have high melting points. Despite the rise of biologics, gene therapies and cell-based medicines, small molecules remain one of the most important therapeutic modalities in drug development. Our teams have decades of experience in the development of these cost-effective and stable therapies for any number of indications including oncology, cardiovascular, neurology, immunology, and rare diseases.

Lipid Based Formulations

Lipid based formulations are useful for bioavailability enhancement of poorly soluble drugs with a high log P and/or difficulty maintain supersaturation solubility. Lipid based formulations can filled into two-piece capsules for convenient clinical dosing.